all Publications

Salas, I.H., Paumier, A., Tao, T., Derevyanko, A., Switzler, C., Burgado, J., Movsesian, M., Metanat, S., Dawoodtabar, T., Asbell, Q., Fassihi, A., Allen, N.J. Astrocyte transcriptomic analysis identifies glypican 5 downregulation as a contributor to synaptic dysfunction in Alzheimer’s disease models. (2024) bioRxiv. DOI: 10.1101/2024.10.30.621182

Deng, J., Labarta-Bajo, L., Brandebura, A.N., Kahn, S.B., Pinto, A.F.M., Diedrich, J.K., Allen, N.J. Suppression of astrocyte BMP signaling improves fragile X syndrome molecular signatures and functional deficits. (2024) bioRxiv. DOI: 10.1101/2024.06.19.599752

Sancho, L., Boisvert, M.M., Dawoodtabar, T., Burgado, J., Wang, E., Allen, N.J. Astrocyte CCN1 stabilizes neural circuits in the adult brain. (2024) bioRxiv. DOI: 10.1101/2024.03.14.585077

Chung, W.S., Baldwin, K.T., Allen, N.J. Astrocyte Regulation of Synapse Formation, Maturation, and Elimination. (2024) Cold Spring Harbor Perspectives in Biology. DOI: 10.1101/cshperspect.a041352

Labarta-Bajo, L., Deng, J., Contreras, M., Allen, N.J. Protocol for the purification and transcriptomic analysis of mouse astrocytes using GFAT. (2023) STAR Protoc. 4(4):102599. DOI: 10.1016/j.xpro.2023.102599

Brandebura, A.N., Asbell, Q.N., Micael, M.K.B., Allen, N.J. Dysregulation of astrocyte-secreted pleiotrophin contributes to neuronal structural and functional phenotypes in Down Syndrome. (2023) bioRxiv. DOI: 10.1101/2023.09.26.559633

Tan, D., Konduri, S., Erikci Ertunc, M., Zhang, P., Wang, J., Chang, T., Pinto, A.F.M., Rocha, A., Donaldson, C.J., Vaughan, J.M., Ludwig, R.G., Willey, E., Iyer, M., Gray, P.C., Maher, P., Allen, N.J., Zuchero, J.B., Dillin, A., Mori, M.A., Kohama, S.G., Siegel, D., Saghatelian, A. A class of anti-inflammatory lipids decrease with aging in the central nervous system. (2022) Nature Chemical Biology. DOI: 10.1038/s41589-022-01165-6

Brandebura, A.N., Paumier, A., Onur, T.S., Allen, N.J. Astrocyte contribution to dysfunction, risk and progression in neurodegenerative disorders. (2022) Nature Reviews Neuroscience. DOI: 10.1038/s41583-022-00641-1

Caldwell, A.L.M., Sancho, L., Deng, J., Bosworth, A., Miglietta, A., Diedrich, J.K., Shokhirev, M.N., Allen, N.J. Aberrant astrocyte protein secretion contributes to altered neuronal development in multiple models of neurodevelopmental disorders. (2022) Nature Neuroscience. DOI: 10.1038/s41593-022-01150-1

Blanco-Suarez, E., Allen, N.J. Astrocyte-secreted chordin-like 1 regulates spine density after ischemic injury. (2022) Scientific Reports. 12(1):4176. DOI: 10.1038/s41598-022-08031-4

Lyon, K.A., Allen, N.J. From Synapses to Circuits, Astrocytes Regulate Behavior. (2022) Front Neural Circuits. 15:786293. DOI: 10.3389/fncir.2021.786293

Farhy-Tselnicker, I., Boisvert, M.M., Liu, H., Dowling, C., Erikson, G.A., Blanco-Suarez, E., Farhy, C., Shokhirev, M.N., Ecker, J.R., Allen, N.J. Activity-dependent modulation of synapse-regulating genes in astrocytes. (2021) Elife. 10. DOI: 10.7554/eLife.70514

Escartin, C., Galea, E., Lakatos, A., O’Callaghan, J.P., Petzold, G.C., Serrano-Pozo, A., Steinhäuser, C., Volterra, A., Carmignoto, G., Agarwal, A., Allen, N.J., Araque, A., Barbeito, L., Barzilai, A., Bergles, D.E., Bonvento, G., Butt, A.M., Chen, W.T., Cohen-Salmon, M., Cunningham, C., Deneen, B., De Strooper, B., Díaz-Castro, B., Farina, C., Freeman, M., Gallo, V., Goldman, J.E., Goldman, S.A., Götz, M., Gutiérrez, A., Haydon, P.G., Heiland, D.H., Hol, E.M., Holt, M.G., Iino, M., Kastanenka, K.V., Kettenmann, H., Khakh, B.S., Koizumi, S., Lee, C.J., Liddelow, S.A., MacVicar, B.A., Magistretti, P., Messing, A., Mishra, A., Molofsky, A.V., Murai, K.K., Norris, C.M., Okada, S., Oliet, S.H.R., Oliveira, J.F., Panatier, A., Parpura, V., Pekna, M., Pekny, M., Pellerin, L., Perea, G., Pérez-Nievas, B.G., Pfrieger, F.W., Poskanzer, K.E., Quintana, F.J., Ransohoff, R.M., Riquelme-Perez, M., Robel, S., Rose, C.R., Rothstein, J.D., Rouach, N., Rowitch, D.H., Semyanov, A., Sirko, S., Sontheimer, H., Swanson, R.A., Vitorica, J., Wanner, I.B., Wood, L.B., Wu, J., Zheng, B., Zimmer, E.R., Zorec, R., Sofroniew, M.V., Verkhratsky, A. Reactive astrocyte nomenclature, definitions, and future directions. (2021) Nature Neuroscience. DOI: 10.1038/s41593-020-00783-4

Sancho, L., Contreras, M., Allen, N.J. Glia as sculptors of synaptic plasticity. (2020) Neurosci Res. DOI: 10.1016/j.neures.2020.11.005

Salas, I.H., Burgado, J., Allen, N.J. Glia: victims or villains of the aging brain? (2020) Neurobiology of Disease.:105008 DOI: 10.1016/j.nbd.2020.105008

Allen, N.J. Brain tumours manipulate neighbouring synapses. (2020) Nature. 578(7793):46-47. DOI: 10.1038/d41586-020-00137-x

Allen, N.J. Star Power: Astrocytes Regulate Behavior. (2019) Cell. 177(5):1091-1093. DOI: 10.1016/j.cell.2019.04.042

Amor, D.J., Stephenson, S.E.M., Mustapha, M., Mensah, M.A., Ockeloen, C.W., Lee, W.S., Tankard, R.M., Phelan, D.G., Shinawi, M., de Brouwer, A.P.M., Pfundt, R., Dowling, C., Toler, T.L., Sutton, V.R., Agolini, E., Rinelli, M., Capolino, R., Martinelli, D., Zampino, G., Dumić, M., Reardon, W., Shaw-Smith, C., Leventer, R.J., Delatycki, M.B., Kleefstra, T., Mundlos, S., Mortier, G., Bahlo, M., Allen, N.J., Lockhart, P.J. Pathogenic Variants in GPC4 Cause Keipert Syndrome. (2019) American Journal of Human Genetics. 104(5):914-924. DOI: 10.1016/j.ajhg.2019.02.026

Dowling, C., Allen, N.J. Mice Lacking Glypican 4 Display Juvenile Hyperactivity and Adult Social Interaction Deficits. (2018) Brain Plasticity. 4(2):197-209. DOI: 10.3233/BPL-180079

Allen, N.J., Lyons, D.A. Glia as architects of central nervous system formation and function. (2018) Science. 362(6411):181-185. DOI: 10.1126/science.aat0473

Blanco-Suarez, E., Liu, T.F., Kopelevich, A., Allen, N.J. Astrocyte-Secreted Chordin-like 1 Drives Synapse Maturation and Limits Plasticity by Increasing Synaptic GluA2 AMPA Receptors. (2018) Neuron. 100(5):1116-1132. DOI: 10.1016/j.neuron.2018.09.043

Farhy-Tselnicker, I., Allen, N.J. Astrocytes, neurons, synapses: a tripartite view on cortical circuit development. (2018) Neural Development. 13(1):7. DOI: 10.1186/s13064-018-0104-y

Allen, N.J., Daneman, R. In Memoriam: Ben Barres. (2018) Journal of Cell Biology. 217(2):435-438. DOI: 10.1083/jcb.201801019

Boisvert, M.M., Erikson, G.A., Shokhirev, M.N., Allen, N.J. The Aging Astrocyte Transcriptome from Multiple Regions of the Mouse Brain. (2018) Cell Reports. 22(1):269-285. DOI: 10.1016/j.celrep.2017.12.039

Zuidema, J.M., Kumeria, T., Kim, D., Kang, J., Wang, J., Hollett, G., Zhang, X., Roberts, D.S., Chan, N., Dowling, C., Blanco-Suarez, E., Allen, N.J., Tuszynski, M.H., Sailor, M.J. Oriented Nanofibrous Polymer Scaffolds Containing Protein-Loaded Porous Silicon Generated by Spray Nebulization. (2018) Advanced Materials. 20(12). DOI: 10.1002/adma.201706785

Allen, N.J., Eroglu, C. Cell Biology of Astrocyte-Synapse Interactions. (2017) Neuron. 96(3):697-708. DOI: 10.1016/j.neuron.2017.09.056

Farhy-Tselnicker, I., van Casteren, A.C.M., Lee, A., Chang, V.T., Aricescu, A.R., Allen, N.J. Astrocyte-Secreted Glypican 4 Regulates Release of Neuronal Pentraxin 1 from Axons to Induce Functional Synapse Formation. (2017) Neuron. 96(2):428-445.e13. DOI: 10.1016/j.neuron.2017.09.053

Bosworth, A.P., Allen, N.J. The diverse actions of astrocytes during synaptic development. (2017) Current Opinion in Neurobiology. 47:38-43. DOI: 10.1016/j.conb.2017.08.017

Allen, N.J. Making Human Stars: A New Method to Generate Human Astrocytes. (2017) Neuron. 95(4):725-727. DOI: 10.1016/j.neuron.2017.08.006

Dwyer, C.A., Scudder, S.L., Lin, Y., Dozier, L.E., Phan, D., Allen, N.J., Patrick, G.N., Esko, J.D. Neurodevelopmental Changes in Excitatory Synaptic Structure and Function in the Cerebral Cortex of Sanfilippo Syndrome IIIA Mice. (2017) Scientific Reports. 7:46576. DOI: 10.1038/srep46576

Blanco-Suárez, E., Caldwell, A.L., Allen, N.J. Role of astrocyte-synapse interactions in CNS disorders. (2017) Journal of Physiology. 595(6):1903-1916. DOI: 10.1113/JP270988

Chung, W.S., Allen, N.J., Eroglu, C. Astrocytes Control Synapse Formation, Function, and Elimination. (2015) Cold Spring Harbor Perspectives in Biology. 7(9):a020370. DOI: 10.1101/cshperspect.a020370

Farhy Tselnicker, I., Boisvert, M.M., Allen, N.J. The role of neuronal versus astrocyte-derived heparan sulfate proteoglycans in brain development and injury. (2014) Biochemical Society Transactions. 42(5):1263-9. DOI: 10.1042/BST20140166

Allen, N.J. Synaptic plasticity: Astrocytes wrap it up. (2014) Current Biology. 24(15):R697-9. DOI: 10.1016/j.cub.2014.06.030

Allen, N.J. Astrocyte regulation of synaptic behavior. (2014) Annual Review of Cell and Developmental Biology. 30:439-63. DOI: 10.1146/annurev-cellbio-100913-013053

Allen, N.J. Role of glia in developmental synapse formation. (2013) Current Opinion in Neurobiology. 23(6):1027-33. DOI: 10.1016/j.conb.2013.06.004

Allen, N.J., Bennett, M.L., Foo, L.C., Wang, G.X., Chakraborty, C., Smith, S.J., Barres, B.A. Astrocyte glypicans 4 and 6 promote formation of excitatory synapses via GluA1 AMPA receptors. (2012) Nature. 486(7403):410-4. DOI: 10.1038/nature11059

Foo, L.C., Allen, N.J., Bushong, E.A., Ventura, P.B., Chung, W.S., Zhou, L., Cahoy, J.D., Daneman, R., Zong, H., Ellisman, M.H., Barres, B.A. Development of a method for the purification and culture of rodent astrocytes. (2011) Neuron. 71(5):799-811. DOI: 10.1016/j.neuron.2011.07.022

Kucukdereli, H., Allen, N.J., Lee, A.T., Feng, A., Ozlu, M.I., Conatser, L.M., Chakraborty, C., Workman, G., Weaver, M., Sage, E.H., Barres, B.A., Eroglu, C. Control of excitatory CNS synaptogenesis by astrocyte-secreted proteins Hevin and SPARC. (2011) Proceedings of the National Academy of Sciences of the United States of America. 108(32):E440-9. DOI: 10.1073/pnas.1104977108

Eroglu, C., Allen, N.J., Susman, M.W., O’Rourke, N.A., Park, C.Y., Ozkan, E., Chakraborty, C., Mulinyawe, S.B., Annis, D.S., Huberman, A.D., Green, E.M., Lawler, J., Dolmetsch, R., Garcia, K.C., Smith, S.J., Luo, Z.D., Rosenthal, A., Mosher, D.F., Barres, B.A. Gabapentin receptor alpha2delta-1 is a neuronal thrombospondin receptor responsible for excitatory CNS synaptogenesis. (2009) Cell. 139(2):380-92. DOI: 10.1016/j.cell.2009.09.025

Allen, N.J., Barres, B.A. Neuroscience: Glia – more than just brain glue. (2009) Nature. 457(7230):675-7. DOI: 10.1038/457675a

De Simoni, A., Allen, N.J., Attwell, D. Charge compensation for NADPH oxidase activity in microglia in rat brain slices does not involve a proton current. (2008) European Journal of Neuroscience. 28(6):1146-56. DOI: 10.1111/j.1460-9568.2008.06417.x

Stevens, B., Allen, N.J., Vazquez, L.E., Howell, G.R., Christopherson, K.S., Nouri, N., Micheva, K.D., Mehalow, A.K., Huberman, A.D., Stafford, B., Sher, A., Litke, A.M., Lambris, J.D., Smith, S.J., John, S.W., Barres, B.A. The classical complement cascade mediates CNS synapse elimination. (2007) Cell. 131(6):1164-78. DOI: 10.1016/j.cell.2007.10.036

Allen, N.J., Barres, B.A. Signaling between glia and neurons: focus on synaptic plasticity. (2005) Current Opinion in Neurobiology. 15(5):542-8. DOI: 10.1016/j.conb.2005.08.006

Allen, N.J., Káradóttir, R., Attwell, D. A preferential role for glycolysis in preventing the anoxic depolarization of rat hippocampal area CA1 pyramidal cells. (2005) Journal of Neuroscience. 25(4):848-59. DOI: 10.1523/JNEUROSCI.4157-04.2005

Allen, N.J., Attwell, D. The effect of simulated ischaemia on spontaneous GABA release in area CA1 of the juvenile rat hippocampus. (2004) Journal of Physiology. 561(Pt 2):485-98. DOI: 10.1113/jphysiol.2004.070490

Allen, N.J., Káradóttir, R., Attwell, D. Reversal or reduction of glutamate and GABA transport in CNS pathology and therapy. (2004) Pflugers Arch. 449(2):132-42. DOI: 10.1007/s00424-004-1318-x

Allen, N.J., Rossi, D.J., Attwell, D. Sequential release of GABA by exocytosis and reversed uptake leads to neuronal swelling in simulated ischemia of hippocampal slices. (2004) Journal of Neuroscience. 24(15):3837-49. DOI: 10.1523/JNEUROSCI.5539-03.2004

Allen, N.J., Attwell, D. Modulation of ASIC channels in rat cerebellar Purkinje neurons by ischaemia-related signals. (2002) Journal of Physiology. 543(Pt 2):521-9. DOI: 10.1113/jphysiol.2002.020297